Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process el 47 0.06 0.966 0.623 0.25
biological_process ka 47 0.0 0.451 0.029 0.082
biological_process rf 47 0.0 0.465 0.031 0.086
cellular_component ct 3 0.0 0.11 0.041 0.049
cellular_component el 3 0.0 0.737 0.247 0.347
cellular_component ka 3 0.002 0.145 0.055 0.064
cellular_component rf 3 0.0 0.11 0.041 0.049
disease ct 12 0.001 0.863 0.193 0.262
disease el 12 0.005 0.806 0.359 0.257
disease ka 12 0.0 0.777 0.187 0.252
disease rf 12 0.001 0.863 0.193 0.263
genetic_interaction el 43 0.0 1.0 0.397 0.335
genetic_interaction ka 43 0.0 0.302 0.13 0.086
genetic_interaction rf 43 0.0 1.0 0.402 0.341
molecular_function ct 3 0.0 0.0 0.0 0.0
molecular_function el 3 0.473 0.578 0.535 0.045
molecular_function ka 3 0.0 0.0 0.0 0.0
molecular_function rf 3 0.0 0.0 0.0 0.0
pathway ct 25 0.0 0.995 0.064 0.194
pathway el 25 0.0 0.207 0.02 0.042
pathway ka 25 0.0 0.051 0.011 0.018
pathway rf 25 0.0 0.168 0.022 0.039
phenotype ct 11 0.0 0.848 0.336 0.323
phenotype el 11 0.179 0.837 0.45 0.217
phenotype ka 11 0.0 0.932 0.383 0.353
phenotype rf 11 0.0 0.876 0.339 0.327
protein_interaction ct 49 0.0 0.235 0.009 0.033
protein_interaction el 49 0.0 0.178 0.008 0.025
protein_interaction ka 49 0.0 0.012 0.001 0.003
protein_interaction rf 49 0.0 0.227 0.009 0.032

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 49 0.0 0.53 0.047 0.12
integration_mean_by_presence el 49 0.0 0.889 0.036 0.135
integration_mean_by_presence ka 49 0.0 0.556 0.028 0.096
integration_mean_by_presence rf 49 0.0 0.207 0.011 0.032
mean ct 49 0.0 0.53 0.046 0.121
mean el 49 0.0 0.493 0.028 0.087
mean ka 49 0.0 0.407 0.027 0.08
mean rf 49 0.0 0.252 0.021 0.058

CDF plots of non integrated kernels

CDF plots of integrated kernels